Dermatoporosis is a new concept proposed to cover different manifestations and implications of chronic cutaneous insufficiency/fragility syndrome. This emerging syndrome extends beyond cosmetics and appearance and is considered to be the functional face of skin aging. With increasing number of elderly population, health care professionals should be aware of the potential epidemics of dermatoporosis. Chronic systemic or topical steroid therapy and chronic exposure to ultraviolet irradiation appear to be the major causes of dermatoporosis. CD44-hyaluronate molecular pathways play an important role in the pathogenesis. Further research and clinical trials are needed to find preventive or therapeutic solutions for dermatoporosis.