History of atopy or autoimmunity increases risk of alopecia areata - 07/08/11
National Alopecia Areata Registry
Correspondence to: Nazila Barahmani, MD, MS, Department of Dermatology, The University of Texas M. D. Anderson Cancer Center, 1400 Pressler, Unit 1452, Houston, TX 77030.Abstract |
Background |
The association between a history of atopy or autoimmune diseases and risk of alopecia areata (AA) is not well established.
Objective |
The purpose of this study was to use the National AA Registry database to further investigate the association between history of atopy or autoimmune diseases and risk of AA.
Methods |
A total of 2613 self-registered sporadic cases (n = 2055) and controls (n = 558) were included in this analysis.
Results |
Possessing a history of any atopic (odds ratio = 2.00; 95% confidence interval 1.50-2.54) or autoimmune (odds ratio = 1.73; 95% confidence interval 1.10-2.72) disease was associated with an increased risk of AA. There was no trend for possessing a history of more than one atopic or autoimmune disease and increasing risk of AA.
Limitations |
Recall, reporting, and recruiting bias are potential sources of limitations in this analysis.
Conclusion |
This analysis revealed that a history of atopy and autoimmune disease was associated with an increased risk of AA and that the results were consistent for both the severe subtype of AA (ie, alopecia totalis and alopecia universalis) and the localized subtype (ie, AA persistent).
Le texte complet de cet article est disponible en PDF.Key words : alopecia areata, atopy, autoimmunity, epidemiology, National Alopecia Areata Registry
Abbreviations used : AA, AAP, AT, AU, IFN, IL, NAAF, NAAR, OR, Th1, Th2
Plan
| Principal investigators of National Alopecia Areata Registry: Hordinsky M, Christiano A, Price VH, Norris D, and Duvic M. |
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| Supported by the National Alopecia Areata Registry (NAAR), a National Institute of Arthritis and Musculoskeletal and Skin Diseases contract NO1-AR-6-2279, and National Alopecia Areata Foundation (NAAF). |
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| Conflicts of interest: None declared. |
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| Reprints not available from the authors. |
Vol 61 - N° 4
P. 581-591 - octobre 2009 Retour au numéro
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