Patterns of photoprotection following CDKN2A/p16 genetic test reporting and counseling - 07/08/11
Abstract |
Background |
The impact of melanoma genetic testing and counseling on photoprotective behaviors is unknown.
Objective |
To determine if genetic testing and counseling alter compliance with photoprotection recommendations.
Methods |
Reported use of sunscreen, protective clothing, and sun avoidance by 59 members of CDKN2A/p16-mutation positive pedigrees was assessed as a function of mutation status and melanoma history, before, immediately after, and 1 month following test reporting.
Results |
Intentions to practice all photoprotective behaviors increased in all participant groups (P < .0001). At 1 month, 33% of participants reported the adoption of a new photoprotective behavior. Subpopulation analyses identified different patterns of change in photoprotection relative to baseline (P < .005), with no net decline in any group.
Limitations |
This initial study of CDKN2A/p16 families is small and awaits replication in a larger sample.
Conclusion |
Melanoma genetic testing and counseling enhanced intentions to implement photoprotective strategies and did not result in reduced compliance in the CDKN2A/p16-subpopulation.
Le texte complet de cet article est disponible en PDF.Key words : CDKN2A, familial melanoma, genetic counseling, prevention, sunscreen use, UV exposure
Abbreviations used : MANOVA, RCR, SD, SPF, UVR
Plan
This work was supported by a Funding Incentive Seed Grant, Office of the Vice President for Research, University of Utah, awarded to Aspinwall and Leachman. Support was also received from the Huntsman Cancer Foundation (HCF), the Tom C. Mathews Jr. Familial Melanoma Research Clinic endowment, the Pedigree and Population Resource of Huntsman Cancer Institute, the National Institutes of Health Office of the Director 1KL2RR025763-01 National Center for Research Resources awarded to University of Utah, and a Templeton Positive Psychology Prize, awarded to Aspinwall by the John Templeton Foundation and the American Psychological Association. We also acknowledge the use of core facilities supported by 5P30CA0420-14 awarded to Huntsman Cancer Institute from the National Cancer Institute Cancer Center Support grants and the use of the genetic counseling core facility supported by the Huntsman Cancer Foundation. Samantha L. Leaf was supported in part by a Graduate Research Fellowship from the Graduate School, University of Utah. |
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Disclosure: Dr Leachman has received honoraria (less than $5000.00 over the past 5 years) from Myriad Genetics for speaking about genetic testing for melanoma. Dr Aspinwall, Dr Leaf, Ms Kohlmann, and Ms Dola declared no conflicts of interest. |
Vol 60 - N° 5
P. 745-757 - mai 2009 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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