Large congenital melanocytic nevi and neurocutaneous melanocytosis: One pediatric center’s experience - 07/08/11
, Jean-Claude Decarie, MD, FRCPC b, Danielle Marcoux, MD, FRCPC a, Catherine McCuaig, MD, FRCPC a, Afshin Hatami, MD, FRCPC a, Pascal Savard, MD, FRCPC a, Julie Powell, MD, FRCPC a
Reprint requests: Catherine Maari, MD, FRCPC, Division of Pediatric Dermatology, Ste-Justine Hospital, 3175, chemin Cote Ste-Catherine, Montreal, Quebec, Canada. H3T 1C5.Abstract |
Background |
Large congenital melanocytic nevi (LCMN) predispose to neurocutaneous melanocytosis (NCM), which is associated with significant morbidity and mortality.
Objective |
To identify risk factors for NCM in patients with LCMN and suggest guidelines for their management.
Methods |
Medical records of patients with LCMN were reviewed at Sainte-Justine Hospital between 1980 and 2006. Presence of multiple satellite nevi and posterior midline location were evaluated as risk factors for NCM using chi-square test. Magnetic resonance imaging scans were reviewed by a neuroradiologist.
Results |
Twenty-six of 52 patients underwent radiologic investigation. Six of 26 (23%) had NCM. Patients with this condition are more likely to have multiple satellite nevi (100% vs 50%, P = .03) and have a trend to posterior midline location of their LCMN (100% vs 60%, P = .08). Patients with NCM are more likely to have both multiple satellite nevi and posterior midline location (100% vs 25%, P = .002). Radiologic findings are also presented.
Limitations |
This was a retrospective case series with imprecise chart data in 38% of cases.
Conclusion |
The presence of multiple satellite nevi alone or with associated posterior midline location of LCMN is associated with a higher risk of NCM. We recommend magnetic resonance imaging testing before 4 months of age in patients with these features.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CI, LCMN, MCMN, MRI, MSN, NCM, NPV, PML, PPV
Plan
| Funding source: None. |
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| Conflicts of interest: None declared. |
Vol 61 - N° 5
P. 766-774 - novembre 2009 Retour au numéro
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