Human β-defensin-2 and psoriasin are overexpressed in lesions of acne inversa - 07/08/11
Reprint requests: Robert E. Hunger, MD, PhD, Department of Dermatology, University of Bern, Inselspital, 3010 Bern, Switzerland.Abstract |
Background |
Acne inversa is a chronic inflammatory disorder of apocrine gland-bearing skin. The role of the innate immune system in the pathogenesis of the disease is controversial.
Objectives |
We investigated the expression of antimicrobial peptide/proteins in acne inversa.
Methods |
Tissue samples were obtained from patients with acne inversa and compared with normal-appearing skin. The expression of psoriasin and human β-defensin (hBD)-2 on messenger RNA and protein level was analyzed.
Results |
Both messenger RNA and protein levels of psoriasin and hBD-2 were significantly increased in acne inversa. Macrophages expressing hBD-2 were found in the dermis.
Limitations |
Small sample size is a limitation.
Conclusions |
Antimicrobial peptide/proteins are overexpressed in acne inversa lesions as compared with normal-appearing skin. The site of the major expression depends on the particular antimicrobial peptide/protein. Psoriasin is overexpressed in epidermal keratinocytes whereas hBD-2 is produced mainly by dermal macrophages, leaving a relative deficiency of hBD-2 in the epidermis of acne inversa lesions.
Le texte complet de cet article est disponible en PDF.Key words : acne inversa, antimicrobial proteins, hBD-2, hidradenitis suppurativa, psoriasin
Abbreviations used : AMP, hBD, mRNA, PCR, TNF
Plan
| Supported by a grant from the Swiss National Foundation (Nr 3200B0-100232). |
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| Conflicts of interest: None declared. |
Vol 61 - N° 1
P. 58-65 - juillet 2009 Retour au numéro
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