A distinct profile of serum levels of soluble intercellular adhesion molecule-1 and intercellular adhesion molecule-3 in mycosis fungoides and Sézary syndrome - 07/08/11
Abstract |
Background |
Cell adhesion molecules (CAMs) play a pivotal role in cutaneous localization of T cells. Tissue-selective localization of T lymphocytes to the skin is crucial for immune surveillance and in the pathogenesis of skin disorders.
Objective |
To detect the profile of soluble CAMs in patients with cutaneous T-cell lymphoma (CTCL), we investigated the levels of intercellular adhesion molecule-1 (ICAM-1, soluble ICAM-1 [sICAM-1]); intercellular adhesion molecule-3 (sICAM-3); vascular cell adhesion molecule-1 (sVCAM-1); and E-selectin (sE-selectin) in sera from patients with T-cell–mediated skin diseases.
Methods |
Serum levels of the 4 CAMs were measured by enzyme-linked immunosorbent assay in 42 participants including 11 patients with early stages of CTCL; 7 with advanced stages of CTCL including Sézary syndrome; 12 with inflammatory skin diseases (psoriasis and atopic dermatitis); 8 with skin diseases that may evolve into CTCL; and healthy individuals. Levels were correlated with biological parameters known as prognostic factors in non-Hodgkin lymphomas.
Results |
In patients with CTCL, significantly increased levels of sICAM-1 and sICAM-3 were found when compared with healthy individuals and patients with inflammatory dermatosis. Soluble E-selectin and sVCAM-1 levels were not increased. There were significant positive correlations between sICAM-1 and sICAM-3 levels and each of them with β2-microglobulin levels.
Limitations |
Limited number of patients was a limitation.
Conclusion |
There is a distinct profile of soluble CAMs in patients with CTCL. However, future studies with a larger group of patients are needed to confirm these findings. We propose that high sICAM-1 and sICAM-3 levels have important implications in the context of immune response and immune surveillance in these patients.
Le texte complet de cet article est disponible en PDF.Key words : cutaneous T-cell lymphoma, soluble E-selectin, soluble intercellular adhesion molecule-1, soluble intercellular adhesion molecule-3, soluble vascular cell adhesion molecule-1
Abbreviations used : aCTCL, CAM, CTCL, ICAM, LDH, LFA, MF, sCAM, sE-selectin, sICAM, sVCAM-1, VCAM-1
Plan
Supported by grants from Agustí Pedro i Pons Foundation and IDIBAPS (Institut d’Investigacions Biomèdiques August Pi i Sunyer). |
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Conflicts of interest: None declared. |
Vol 61 - N° 2
P. 263-270 - août 2009 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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