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Trends in incidence of adult-onset psoriasis over three decades: A population-based study - 08/08/11

Doi : 10.1016/j.jaad.2008.10.062 
Murat Icen, MD a, Cynthia S. Crowson, MS a, Marian T. McEvoy, MD b, Frank J. Dann, MD c, Sherine E. Gabriel, MD, MSc a, Hilal Maradit Kremers, MD, MSc a,
a Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota 
b Department of Dermatology, College of Medicine, Mayo Clinic, Rochester, Minnesota 
c VA Healthcare System, Long Beach, California 

Reprint requests: Hilal Maradit Kremers, MD, MSc, Mayo Clinic, Department of Health Sciences Research, Division of Epidemiology, 200 First St SW, Rochester, MN 55905.

Abstract

Background

Incidence studies of psoriasis are rare, mainly due to lack of established epidemiological criteria and the variable disease course. The objective of this study is to determine time trends in incidence and survival of psoriasis patients over three decades.

Methods

We identified a population-based incidence cohort of 1633 subjects aged ≥18 years first diagnosed with psoriasis between January 1, 1970 and January 1, 2000. The complete medical records for each potential psoriasis subject were reviewed and diagnosis was validated by either a confirmatory diagnosis in the medical record by a dermatologist or medical record review by a dermatologist. Age- and sex-specific incidence rates were calculated and were age- and sex-adjusted to the 2000 US white population.

Results

The overall age- and sex-adjusted annual incidence of psoriasis was 78.9 per 100,000 (95% confidence interval [CI]: 75.0-82.9). When psoriasis diagnosis was restricted to dermatologist-confirmed subjects, the incidence was 62.3 per 100,000 (95% CI: 58.8-65.8). Incidence of psoriasis increased significantly over time from 50.8 in the period 1970-1974 to reach 100.5 per 100,000 in the 1995-1999 time period (P = .001). Although the overall incidence was higher in males than in females (P = .003), incidence in females was highest in the sixth decade of life (90.7 per 100,000). Survival was similar to that found in the general population (P = .36).

Limitations

The study population was mostly white and limited to adult psoriasis patients.

Conclusion

The annual incidence of psoriasis almost doubled between the 1970s and 2000. The reasons for this increase in incidence are currently unknown, but could include a variety of factors, including a true change in incidence or changes in the diagnosing patterns over time.

Le texte complet de cet article est disponible en PDF.

Key words : epidemiology, population-based study, psoriasis

Abbreviations used : CI, ICD, PUVA, SMR


Plan


 Supported by an unrestricted research grant from Amgen Inc and AR30582 from NIAMS.
 Disclosure: Dr Kremers has received consulting fees, speaking fees, and/or honoraria (less than $10,000) from Amgen. Dr Dann is a former Amgen employee, holds Amgen stock, and has a consultancy agreement with Amgen. Drs Icen, Crowson, McEvoy, and Gabriel declared no conflicts of interest.


© 2008  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 60 - N° 3

P. 394-401 - mars 2009 Retour au numéro
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