Médecine

Paramédical

Autres domaines


S'abonner

Alefacept with methotrexate for treatment of psoriatic arthritis: Open-label extension of a randomized, double-blind, placebo-controlled study - 08/08/11

Doi : 10.1016/j.jaad.2008.09.050 
Philip J. Mease, MD a, , Kristian Reich, MD b

Alefacept in Psoriatic Arthritis Study Group

  Please see Appendix for a list of participating investigators and sites.

a Swedish Medical Center, Seattle, Washington 
b Dermatologikum Hamburg, Hamburg, Germany 

Reprint requests: Philip J. Mease, MD, Seattle Rheumatology Associates, Division of Rheumatology Research, Swedish Medical Center, 1101 Madison St, Suite 1000, Seattle, WA.

Abstract

Background

A single course of alefacept intramuscularly in combination with methotrexate (MTX) was effective in treating both psoriasis and psoriatic arthritis (PsA).

Objective

We sought to determine the efficacy and safety of an additional course of alefacept intramuscularly in combination with MTX in patients with PsA.

Methods

In this open-label extension study, patients with PsA on stable doses of MTX were treated with an additional 12 weekly intramuscular injections of alefacept followed by 12 weeks of observation. Efficacy of PsA treatment was measured as 20% reduction in American College of Rheumatology criteria (ACR20).

Results

At the end of the open-label extension phase, 86 of 160 (54%) patients achieved ACR20, of which 28 of 55 had received placebo plus MTX and 58 of 105 received alefacept plus MTX in the prior double-blind phase. Although there was no increase in the proportion of patients achieving ACR20 after a second course of alefacept plus MTX, those achieving ACR50 and ACR70 increased from 17% and 7%, respectively, in the double-blind phase to 32% and 12%, respectively, in the open-label extension phase.

Limitations

In this open-label extension phase of the study there was no control group and the effect on psoriasis in these patients was not measured.

Conclusions

Patients with psoriasis and PsA on stable doses of MTX derive benefit for both conditions from one or more courses of alefacept, with further benefit in PsA apparent after a second course of treatment. No additional toxicity was observed.

Le texte complet de cet article est disponible en PDF.

Abbreviations used : ACR, ACR20, ALT, AST, MTX, PASI, PsA, ULN


Plan


 The data presented in this article are from a clinical trial sponsored by Biogen Idec. Astellas Pharma US, Inc acquired ownership of Amevive (alefacept) effective April 14, 2006, and has subsequently supported the publication of this study.
 Disclosure: Dr Mease has been: (1) a consultant for and an investigator on trials sponsored by Abbott, Amgen, Biogen Idec, Bristol Myers Squibb, Centocor, Genentech, and Wyeth for which he received grants; (2) a consultant for Serono and UCB for which he received honoraria; and (3) a speaker for Abbott, Amgen, Biogen Idec, Bristol Myers Squibb, Centocor, Genentech, and Wyeth for which he received honoraria. Dr Reich has been: (1) a member of an advisory board, a speaker, and an investigator on trials sponsored by Abbott for which he received grants and honoraria; (2) a member of an advisory board, a speaker, and an investigator on trials sponsored by Centocor, Schering-Plough, Serono, UCB, and Wyeth for which he received honoraria; (3) a speaker and an investigator on trials sponsored by Biogen Idec for which he received honoraria; and (4) a member of an advisory board and a speaker for Cilag for which he received honoraria.
 Presented in part at the Winter Clinical Dermatology Conference in Kapalua, Hawaii, on January 13-17, 2006.


© 2008  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
Ajouter à ma bibliothèque Retirer de ma bibliothèque Imprimer
Export

    Export citations

  • Fichier

  • Contenu

Vol 60 - N° 3

P. 402-411 - mars 2009 Retour au numéro
Article précédent Article précédent
  • Trends in incidence of adult-onset psoriasis over three decades: A population-based study
  • Murat Icen, Cynthia S. Crowson, Marian T. McEvoy, Frank J. Dann, Sherine E. Gabriel, Hilal Maradit Kremers
| Article suivant Article suivant
  • Change of Address

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

;

Mon compte


Plateformes Elsevier Masson

Déclaration CNIL

EM-CONSULTE.COM est déclaré à la CNIL, déclaration n° 1286925.

En application de la loi nº78-17 du 6 janvier 1978 relative à l'informatique, aux fichiers et aux libertés, vous disposez des droits d'opposition (art.26 de la loi), d'accès (art.34 à 38 de la loi), et de rectification (art.36 de la loi) des données vous concernant. Ainsi, vous pouvez exiger que soient rectifiées, complétées, clarifiées, mises à jour ou effacées les informations vous concernant qui sont inexactes, incomplètes, équivoques, périmées ou dont la collecte ou l'utilisation ou la conservation est interdite.
Les informations personnelles concernant les visiteurs de notre site, y compris leur identité, sont confidentielles.
Le responsable du site s'engage sur l'honneur à respecter les conditions légales de confidentialité applicables en France et à ne pas divulguer ces informations à des tiers.