A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers - 08/08/11
Abstract |
Objective |
We sought to compare total lidocaine dose and patient comfort when using 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine during Mohs micrographic surgery.
Methods |
In all, 149 patients were randomized to receive 1.0% lidocaine with 1:100,000 epinephrine or 0.5% lidocaine with 1:200,000 epinephrine during Mohs micrographic surgery. The total dose of lidocaine and measures of patient comfort were recorded.
Results |
Compared with the 1.0% lidocaine group, there was a 52% reduction in lidocaine dose in the 0.5% group (mean difference, 147.85 mg; 95% confidence interval, 108.15-187.55; P < .001). Patient comfort was equivalent in both groups, as evidenced by the similar mean visual analog scale scores (P = .48) and mean volumes of rescue lidocaine administered (P = .18).
Limitations |
No lidocaine blood levels were measured, and one Mohs surgeon performed all surgeries.
Conclusion |
The dose of 0.5% lidocaine with 1:200,000 epinephrine provides pain control equivalent to 1.0% lidocaine with 1:100,000 epinephrine at approximately half the total lidocaine dose.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CI, IQR, VAS
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
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Oral platform presentation at the American College of Mohs Surgery Annual Meeting, Vancouver, British Columbia, May 1, 2008. |
Vol 60 - N° 3
P. 444-452 - mars 2009 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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