The role of Malassezia in atopic dermatitis affecting the head and neck of adults - 08/08/11
Abstract |
Atopic dermatitis is a common chronic skin condition. A subset of patients with head and neck dermatitis may have a reaction to Malassezia flora fueling their disease. Although there are no documented differences in Malassezia species colonization, patients with head and neck atopic dermatitis are more likely to have positive skin prick test results and Malassezia-specific IgE compared with healthy control subjects and patients with atopy without head and neck dermatitis. There is no clear relationship with atopy patch testing. The reaction to Malassezia is likely related to both humoral- and cell-mediated immunity. Clinically, Malassezia allergy may be suspected in patients with atopic dermatitis and: (1) head and neck lesions; (2) exacerbations during adolescence or young adulthood; (3) severe lesions recalcitrant to conventional therapy; and (4) other atopic diseases. There is literature to suggest that these patients will benefit from a 1- to 2-month course of daily itraconazole or ketoconazole followed by long-term weekly treatment.
Le texte complet de cet article est disponible en PDF.Abbreviations used : AD, APT, DC, HND, IL, MHC, SPT
Plan
Funding sources: None. |
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Disclosure: Dr Bechtel has been a paid consultant and is on speakers bureau for Genetech, Abbott, Centocor, and Biogen-Idec. Dr Zirwas has received honoraria from Coria Labs and Astellas Pharma. Dr Darabi and Ms Hostetler have no conflicts of interest to declare. |
Vol 60 - N° 1
P. 125-136 - janvier 2009 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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