Is There a Better Way to Biopsy the Prostate? Prospects for a Novel Transrectal Systematic Biopsy Approach - 08/08/11

Doi : 10.1016/j.urology.2007.06.1128

Gerald L. Andriole ^a,^⁎,^{^{1
Dr. Andriole is a paid consultant to Aeterna Zentaris, Onconomica, Roche, Solvay, and Viking Medical Systems; is a study investigator partially funded by Antigenics, GlaxoSmithKline, CD Searle, and Zeneca; and has financial interests in Envisioneering and Viking Medical Systems.}} , Travis L. Bullock ^a,^{^{3
Dr. Bullock has no financial arrangement or affiliation with a corporate organization or a manufacturer of a product discussed in this supplement.}}, Jay S. Belani ^a,^{^{4
Dr. Belani has no financial arrangement or affiliation with a corporate organization or a manufacturer of a product discussed in this supplement.}}, Erica Traxel ^a,^{^{5
Dr. Traxel has no financial arrangement or affiliation with a corporate organization or a manufacturer of a product discussed in this supplement.}}, Yan Yan ^a,^{^{6
Dr. Yan has no financial arrangement or affiliation with a corporate organization or a manufacturer of a product discussed in this supplement.}}, David G. Bostwick ^b,^{^{2
Dr. Bostwick is a study investigator for Bioniche, Dendreon, DiagnoCure, Endocare, Genotherapeutics, GlaxoSmithKline, and Health Tronics; and is the founder and majority shareholder in Bostwick Laboratories.}}, Peter A. Humphrey ^c,^{^{7
Dr. Humphrey has no financial arrangement or affiliation with a corporate organization or a manufacturer of a product discussed in this supplement.}}
^a Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA
^b Bostwick Laboratories, Richmond, Virginia, USA
^c Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA

Reprint requests: Gerald L. Andriole, MD, Division of Urologic Surgery, Washington University School of Medicine, 4960 Children’s Place, Campus Box 8242, St. Louis, Missouri 63110.

Résumé

The study reported here was undertaken to investigate a novel method of systematic, 3-dimensional, template-guided, transrectal ultrasound–guided prostate biopsy. The TargetScan transrectal ultrasound and prostatic biopsy system (Envisioneering Medical Technologies, St. Louis, MO) uses a stationary transrectal ultrasound probe that acquires 3-dimensional and simultaneous biplanar ultrasound imaging. With the use of prostate-specific measurements, targeted transrectal biopsy specimens of the prostate are taken. The precise location of each specimen is defined by 2 coordinates: depth in centimeters proximal from the apex of the prostate, and degree of rotation (clockwise or counterclockwise from 12 o’clock). This device has been evaluated when used with radical prostatectomy specimens. Studies on 20 radical prostatectomy specimens disclosed that simulated TargetScan biopsy correctly identified cancer in 16 (80%) prostates and high-grade prostatic intraepithelial neoplasia in 2 others. Simulated TargetScan biopsy correctly characterized 88% of prostatic octants in terms of whether or not they harbored cancer. This technique was reproducible from operator to operator, and 85% biopsy core concordance was attained when the TargetScan protocol was simulated in 2 urology residents. The TargetScan biopsy system seems to be an effective transrectal alternative to transperineal, 3-dimensional, ultrasound-guided biopsies. Its reproducibility from operator to operator suggests that it may be useful for guiding rebiopsy of specific locations within the prostate and for providing targeted focal prostate cancer therapy.

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Vol 70 - N° 6S1

P. S22-S26 - décembre 2007 Retour au numéro

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“Male Lumpectomy”: Focal Therapy for Prostate Cancer Using Cryoablation
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Appropriate Patient Selection in the Focal Treatment of Prostate Cancer: The Role of Transperineal 3-Dimensional Pathologic Mapping of the Prostate—A 4-Year Experience
Winston E. Barzell, Myron R. Melamed

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Is There a Better Way to Biopsy the Prostate? Prospects for a Novel Transrectal Systematic Biopsy Approach - 08/08/11

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