The effects of laser-mediated hair removal on immunohistochemical staining properties of hair follicles - 09/08/11
, Craig Hammerberg, PhD a, Lori Lowe, MD a, b, Sewon Kang, MD a, Timothy M. Johnson, MD a, Ted Hamilton, MS a, John J. Voorhees, MD, FRCP a, Gary J. Fisher, PhD a
Reprint requests: Jeffrey S. Orringer, MD, Department of Dermatology, University of Michigan Medical School, 1500 E Medical Center Dr, 1910 Taubman Center, Ann Arbor, MI 48109-0314.Ann Arbor, Michigan
Abstract |
Background |
The mechanisms involved in laser-mediated hair removal remain unclear. One means of reducing hair growth is alteration of follicular stem cells.
Objective |
We sought to examine the effects of laser hair removal on the immunohistochemical staining properties of human hair follicles, including the putative stem cells of the bulge region.
Methods |
Treatment of unwanted axillary hair was performed on one side using an 800 nm–wavelength diode laser and on the other side using a 1064 nm–wavelength neodymium:yttrium-aluminum-garnet laser. Serial skin samples were obtained at baseline and various times after treatment and stained using immunohistochemical techniques.
Results |
Hair shafts were thermally altered, but the immunostaining properties of much of the follicle, including the bulge region, remained generally unchanged.
Limitations |
This study only addressed the acute immunohistochemical changes found after a single treatment using specific laser parameters.
Conclusions |
Laser-mediated hair removal does not appear to work by frank destruction of follicular stem cells. Other mechanisms including functional alteration of these cells may underlie the clinical efficacy of the procedure.
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| Supported by the University of Michigan Department of Dermatology Cosmetic Dermatology and Laser Research Fund. Conflicts of interest: None identified. |
Vol 55 - N° 3
P. 402-407 - septembre 2006 Retour au numéro
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