Foreign body granuloma caused by monosodium glutamate after BCG vaccination - 09/08/11
Hualien and Kaohsiung, Taiwan
Abstract |
We describe a 7-month-old male infant with a foreign body granuloma caused by monosodium glutamate (MSG) after a Bacille Calmette-Guérin (BCG) immunization. A ridged, erythematous, indurated plaque developed over a BCG injection site on his left upper arm 1 month after the first BCG immunization. Biopsy showed multiple noncaseating foreign body granulomas without detectable mycobacteria by both Ziehl-Neelsen stain and polymerase chain reaction assay. Birefringent crystals were identified in the foreign body giant cells with polarized light microscopy. The crystals were further determined to be glutamic acid by the method of fast atom bombardment. Hence, MSG, the only composite of BCG vaccine except the bacillus, was believed to be responsible for the granulomatous foreign body reaction. On review of the literature, we could find no previous report of an adverse reaction of BCG immunization attributable to MSG (glutamic acid).
Le texte complet de cet article est disponible en PDF.Abbreviations used : BCG, FAB, MSG, PCR
Plan
Production and distribution supported by an educational grant to the American Academy of Dermatology by Stiefel Laboratories, Inc. Funding sources: None. Conflicts of interest: None identified. |
Vol 55 - N° 2S
P. S1-S5 - août 2006 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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