Microdermabrasion with and without aluminum oxide crystal abrasion: A comparative molecular analysis of dermal remodeling - 09/08/11
, Sewon Kang, MD, Timothy M. Johnson, MD, Jeffrey S. Orringer, MD, Ted Hamilton, MS, Craig Hammerberg, PhD, John J. Voorhees, MD, Gary Fisher, PhD
Reprint requests: Darius J. Karimipour, MD, University of Michigan, 1500 E Medical Center Dr, Department of Dermatology, 1910 Taubman Center, Ann Arbor, MI 48109-0314.Ann Arbor, Michigan
Abstract |
Background |
Microdermabrasion is a popular method of superficial skin resurfacing with effects on dermal remodeling.
Objective |
The purpose of this study was to evaluate the relative importance of the two components of microdermabrasion, negative pressure and abrasion, in stimulating expression of key genes involved in dermal remodeling.
Methods |
Ten subjects were treated with a microdermabrasion machine using focal crystal abrasion and negative pressure or negative pressure alone for 3 seconds. Serial biochemical analyses were performed. Reverse transcriptase real-time polymerase chain reaction assays were used to evaluate changes in transcription factor activator protein-1, primary cytokines (interleukin 1β, tumor necrosis factor-⍺), and matrix metalloproteinases (MMP-1, MMP-3, MMP-9).
Results |
Significant increases in gene expression of the c-Jun component of activator protein-1, interleukin 1β, tumor necrosis factor-⍺, MMP-1, MMP-3, and MMP-9 were found with crystal abrasion combined with negative pressure. Negative pressure alone resulted in increased gene expression of MMP-1 and MMP-3 but of a quantitatively reduced magnitude when compared with negative pressure with crystal abrasion.
Limitations |
It is unclear that molecular changes seen with these treatments can result in clinical effect.
Conclusion |
The abrasive component of microdermabrasion is necessary for stimulating expression of key genes involved in dermal remodeling.
Le texte complet de cet article est disponible en PDF.Abbreviations used : AP-1, IL, MMP, NF, RT-PCR, TNF
Plan
| Funding sources: Research for this article supported by the Skin Surgical Research Fund at the University of Michigan, Bella Products, and a Dermatology Foundation Clinical Career Development Award (to D. J. K.). Bella Products donated the microdermabrasion machine, hand pieces, and crystals. Bella Products had no knowledge of the outcomes of this study. As a condition of acceptance of the donated equipment from Bella Products, the study was designed to be performed, analyzed, and reported solely by the faculty and staff of the Department of Dermatology at the University of Michigan. Conflicts of interest: None identified. |
Vol 54 - N° 3
P. 405-410 - mars 2006 Retour au numéro
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