Congenital leukemia cutis with subsequent development of leukemia - 09/08/11
Reprint requests: Mignon L. Loh, MD, Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143-0519.San Francisco, California
Abstract |
We describe a newborn infant who was born with a purpuric rash and subcutaneous nodules. Skin biopsies demonstrated acute myeloid leukemia. Cytogenetic studies revealed an 11q23 rearrangement. Initial bone marrow and cerebrospinal fluid examination did not demonstrate medullary or meningeal disease. Chemotherapy was initiated on the basis of the abnormal cytogenetic findings in the skin biopsy. Intensive chemotherapy was, given but the infant’s leukemia progressed. The patient died of refractory leukemia and secondary fungal disease. This case report supports the observation that leukemia cutis with an 11q23 rearrangement should be treated aggressively.
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| Supported by Stiefel Laboratories. Funding sources: B. B. and M. L. L. are supported by the Frank Campini Foundation. M. L. L. is also supported by NIH grants CA104282, CA 095621, the Hope Street Kids Foundation, and the Jeffrey and Karen Peterson Family Foundation. Conflicts of interest: None identified. |
Vol 54 - N° 2S
P. S22-S27 - février 2006 Retour au numéro
Article précédent
- Severe erythema multiforme responding to interferon alfa
- Pedram Geraminejad, Hobart W. Walling, Michael D. Voigt, Mary Seabury Stone
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- Yin Yin Vun, Brad Jones, Muammer Al-Mudhaffer, Conleth Egan
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