Henoch-Schönlein purpura associated with malignancy in adults - 09/08/11
New York, New York
Abstract |
Malignancy is a well-known cause of cutaneous vasculitis. The occurrence of neoplasia and Henoch-Schönlein purpura (HSP) is rare and poorly understood in adults. A total of 31 cases have been reported in the world literature of adult malignancy-associated HSP. Patients were overwhelmingly male (94%) with a mean age of 60 years and presented predominantly with solid tumors (61%). The most frequent tumors were lung (nonsmall-cell) (n = 8), multiple myeloma (n = 5), prostate (n = 5), and non-Hodgkin’s lymphoma (n = 3). The majority of patients (55%) developed HSP within 1 month of cancer diagnosis or detection of metastases. We present 3 cases of adults who, in the absence of known precipitating factors, developed HSP within 2 months of diagnosis of a solid tumor or metastases. We recommend that adults, especially older men who present with unexplained HSP, be evaluated for occult neoplasm. We also advise that patients with a known history of malignancy who present with HSP be evaluated for metastatic disease.
Le texte complet de cet article est disponible en PDF.Abbreviations used : C3, CT, DIF, LCV, RPR, HSP
Plan
Production and distribution supported by an educational grant to the American Academy of Dermatology by Stiefel Laboratories, Inc. Funding sources: None. Conflicts of interest: None identified. |
Vol 55 - N° 5S
P. S65-S70 - novembre 2006 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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