A randomized, double-blind, vehicle-controlled, bilateral comparison trial of bexarotene gel 1% versus vehicle gel in combination with narrowband UVB phototherapy for moderate to severe psoriasis vulgaris - 09/08/11
New Brunswick, New Jersey
Abstract |
We report results of a randomized, vehicle-controlled, bilateral comparison pilot study of bexarotene gel 1% with narrowband UVB (NBUVB) phototherapy for moderate to severe psoriasis. In all, 9 patients applied drug or vehicle gel to comparable target lesions up to twice daily for 10 weeks. NBUVB was initiated 2 weeks after topical therapy began. Limitations include small sample size and interim analysis. Based on analysis of target lesion scores, bexarotene gel 1%/NBUVB was significantly more effective than placebo/NBUVB.
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Supported by a grant from Ligand Pharmaceuticals Inc. Narrowband UVB phototherapy unit was donated by UVBioTek. Conflicts of interest: None identified. Previously presented as a poster at the Fifth Annual Meeting of the Federation of Clinical Immunology Societies in Boston, Mass, on May 12-16, 2005. |
Vol 54 - N° 1
P. 115-118 - janvier 2006 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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