Infantile acne as the initial sign of an adrenocortical tumor - 12/08/11
St Louis, Missouri
Abstract |
A 23-month-old boy with persistent acne since 6 months of age had signs of virilization and accelerated growth. Hormone evaluation indicated increased levels of dehydroepiandrosterone (DHEA) and testosterone. Ultrasound and abdominal computed tomographic scan revealed a large adrenal mass consistent with an adrenocortical tumor. The patient underwent surgical excision of the well-encapsulated tumor with normalization of his hormones and no subsequent recurrence. Although rare, childhood adrenocortical tumors have a poor prognosis, with the majority of tumors having regional and metastatic disease. Because early diagnosis and complete surgical excision improve prognosis, children with refractory infantile acne should be evaluated for signs of virilization and accelerated growth. Laboratory evaluation should include luteinizing hormone, follicle-stimulating hormone, total and free testosterone cortisol, DHEA, and its sulfate (DHEA-S). Elevated levels of DHEA and DHEA-S should prompt an aggressive diagnostic evaluation for an adrenocortical tumor.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CT, DHEA, DHEA-S
Plan
Funding sources: None. Conflicts of interest: None declared. |
Vol 56 - N° 2S
P. S15-S18 - février 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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