Pemphigus vulgaris presenting in a radiation portal - 12/08/11
Reprint requests: Janet A. Fairley, MD, Department of Dermatology, UIHC, BT-2090, 200 Hawkins Dr, Iowa City, IA.Milwaukee, Wisconsin
Abstract |
We report a case of mucocutaneous pemphigus vulgaris in a patient with squamous cell carcinoma of the lung. The cutaneous involvement was limited to the skin within his therapeutic radiation portal. The diagnosis of pemphigus vulgaris was confirmed by histopathology and immunologic studies. Direct immunofluorescence demonstrated IgG and C3 in the intercellular spaces and indirect immunofluorescence was positive on monkey esophagus at a titer of 1:160. Enzyme-linked immunosorbent assay of the patient’s serum detected autoantibodies only to desmoglein (Dsg)3, with no reactivity to Dsg1. Immunomapping of perilesional skin from the irradiated field illustrated decreased Dsg1 expression compared with a control sample from an area that was not exposed to radiation. This case provides support for the Dsg compensation hypothesis and may also suggest a mechanism by which irradiation may induce skin lesions.
Le texte complet de cet article est disponible en PDF.Abbreviations used : Dsg, IF, PV
Plan
| Supported in part from a Merit Review Award from the Department of Veterans Affairs (Dr Fairley). Conflicts of interest: None declared. |
Vol 56 - N° 5S
P. S82-S85 - mai 2007 Retour au numéro
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