Allergic contact dermatitis from pimecrolimus in a patient with tacrolimus allergy - 12/08/11
San Diego and San Francisco, California
Abstract |
A 15-year-old male with previously documented allergic contact dermatitis from tacrolimus was allergic to pimecrolimus. This was demonstrated by double-blinded, right-versus-left provocative use testing with pimecrolimus cream 1% versus inactive vehicle applied twice daily to normal skin. The active cream but not its vehicle caused preauricular dermatitis starting after 1 week and caused isolated papules on the extensor wrist starting after 2 weeks. Patch testing on the patient’s back was weakly positive (1+) with pimecrolimus cream 1% and negative with the vehicle. Higher concentrations of pimecrolimus were not available for testing. Patch tests on 30 control patients with pimecrolimus cream 1% were negative.
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Funding sources: None. Dr Eichenfield has received funding from Astellas Pharma and Novartis Pharmaceuticals for clinical studies. Reprints not available from the authors. |
Vol 56 - N° 2
P. 342-345 - février 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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