Systematic review of rosacea treatments - 12/08/11
Leiden, The Netherlands; Toronto and London, Ontario, Canada; Iowa City, Iowa; and Lancaster, United Kingdom
Abstract |
Background |
Rosacea is a common chronic skin and ocular condition. It is unclear which treatments are most effective. We have conducted a Cochrane review of rosacea therapies.1 This article is a distillation of that work.
Objective |
We sought to assess the evidence for the efficacy and safety of rosacea therapies.
Methods |
Multiple databases were systematically searched. Randomized controlled trials in people with moderate to severe rosacea were included. Study selection, assessment of methodologic quality, data extraction, and analysis were carried out by two independent researchers.
Results |
In all, 29 studies met inclusion criteria. Topical metronidazole is more effective than placebo (odds ratio 5.96, 95% confidence interval 2.95-12.06). Azelaic acid is more effective than placebo (odds ratio 2.45, 95% confidence interval 1.82-3.28). Firm conclusions could not be drawn about other therapies.
Limitations |
The quality of the studies was generally poor.
Conclusions |
There is evidence that topical metronidazole and azelaic acid are effective. There is some evidence that oral metronidazole and tetracycline are effective. More well-designed, randomized controlled trials are required to provide better evidence of the efficacy and safety of other rosacea therapies.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CI, OR, RCT
Plan
Funding sources: None. Conflicts of interest: None identified. This manuscript is based on an earlier publication by van Zuuren et al,1 copyright Cochrane Library, reproduced with permission. |
Vol 56 - N° 1
P. 107-115 - janvier 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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