HLA-DR association with the genetic susceptibility to develop ashy dermatosis in Mexican Mestizo patients - 12/08/11
Mexico City, Mexico
Abstract |
Background |
Ashy dermatosis, also known as erythema dyschromicum perstans, is an acquired benign disease, characterized by blue-gray pigment patches with erythematous borders. The cause is still unclear, but probably has an immunologic basis.
Objective |
The aim of this study was to determine gene frequencies of the HLA-DR alleles in Mexican patients with ashy dermatosis and compare them with ethnically matched healthy control subjects to reveal the genetic susceptibility to develop ashy dermatosis.
Methods |
We included 23 consecutive patients with clinical and histopathologic confirmed diagnosis of erythema dyschromicum perstans. Patients and control subjects received a questionnaire to determine their ethnic origin and a peripheral blood sample was taken for DNA extraction. Finally, Genetic HLA-DRB1 was performed by polymerase chain reaction sequence-specific oligonucleotide reverse dot blot hybridization.
Results |
Of the 23 patients included in this study, 65% were women and 35% were men. We observed that the disease was located in the trunk in 17 patients (74%) and the upper limbs in 15 patients (65%). The most frequent allele was HLA-DR4 (65%) (pC < 1 × 10−6, odds ratio = 6.0, 95% confidence interval = 2.8-12.7) whereas in control subjects it was 23%. The most frequent molecular subtype in both patients and healthy control subjects was DRB10407, being statistically significant after comparing the two groups (pC < 1 × 10−6, odds ratio = 7.0, 95% confidence interval = 3.1-15.8).
Limitations |
Since this is a disease strongly influenced by ethnicity, extrapolation to other ethnic groups is limited.
Conclusions |
Many factors influence the ethiopathogenesis of erythema dyschromicum perstans, but it is strongly suggested to have an important genetic susceptibility conferred by genes located within the major histocompatibility complex region.
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Funding sources: None. Conflicts of interest: None identified. |
Vol 56 - N° 4
P. 617-620 - avril 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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