Epidermodysplasia verruciformis in the setting of graft-versus-host disease - 19/08/11
Abstract |
We report a case of epidermodysplasia verruciformis (EV)-like lesions in a patient with graft-versus-host disease after peripheral blood stem cell transplantation from his HLA-matched brother. The patient presented with a diffuse papular eruption that was clinically consistent with graft-versus-host disease; however, histopathology demonstrated viral cytopathic changes and polymerase chain reaction confirmed EV human papillomavirus types 8 and 20. Repeated biopsy specimen showed both human papillomavirus cytopathic effect and graft-versus-host disease, and further workup revealed ocular and hepatic involvement. This progressed to a lupuslike syndrome with lichenoid, violaceous, flat-topped papules in a malar distribution and positive antinuclear autoantibodies. Although EV-like lesions have been reported in patients who are immunocompromised, the incidence is low, and may be linked to EV-related haplotypes.
Le texte complet de cet article est disponible en PDF.Abbreviations used : EV, GVHD, HPV
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
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Presented as a poster at the 42nd Annual Meeting of the American Society of Dermatopathology in Seattle, Washington, on October 23-25, 2005. |
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Reprints not available from the authors. |
Vol 57 - N° 5S
P. S78-S80 - novembre 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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