Epidermodysplasia verruciformis in the setting of graft-versus-host disease - 19/08/11
, Vandana Madkan, MD e, Angela J. Wyatt, MD c, David Uptmore, MD a, Alexander J.F. Lazar, MD, PhD c, Sergio Giralt, MD d, Peter Rady, MD, PhD a, Stephen Tyring, MD, PhD, MBA a
Correspondence to: Sharon R. Hymes, MD, Department of Dermatology, M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030.Abstract |
We report a case of epidermodysplasia verruciformis (EV)-like lesions in a patient with graft-versus-host disease after peripheral blood stem cell transplantation from his HLA-matched brother. The patient presented with a diffuse papular eruption that was clinically consistent with graft-versus-host disease; however, histopathology demonstrated viral cytopathic changes and polymerase chain reaction confirmed EV human papillomavirus types 8 and 20. Repeated biopsy specimen showed both human papillomavirus cytopathic effect and graft-versus-host disease, and further workup revealed ocular and hepatic involvement. This progressed to a lupuslike syndrome with lichenoid, violaceous, flat-topped papules in a malar distribution and positive antinuclear autoantibodies. Although EV-like lesions have been reported in patients who are immunocompromised, the incidence is low, and may be linked to EV-related haplotypes.
Le texte complet de cet article est disponible en PDF.Abbreviations used : EV, GVHD, HPV
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
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| Presented as a poster at the 42nd Annual Meeting of the American Society of Dermatopathology in Seattle, Washington, on October 23-25, 2005. |
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| Reprints not available from the authors. |
Vol 57 - N° 5S
P. S78-S80 - novembre 2007 Retour au numéro
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