The effect of a high-protein, low glycemic–load diet versus a conventional, high glycemic–load diet on biochemical parameters associated with acne vulgaris: A randomized, investigator-masked, controlled trial - 19/08/11
Reprint requests: Robyn Smith, BAppSc (Hons), School of Applied Sciences, RMIT University, GPO Box 2476V, Melbourne, Victoria, Australia, 3001.Melbourne and Parkville, Australia; and Turku, Finland
Abstract |
Background |
No previous study has sought to examine the influence of dietary composition on acne vulgaris.
Objective |
We sought to compare the effect of an experimental low glycemic–load diet with a conventional high glycemic–load diet on clinical and endocrine aspects of acne vulgaris.
Methods |
A total of 43 male patients with acne completed a 12-week, parallel, dietary intervention study with investigator-masked dermatology assessments. Primary outcomes measures were changes in lesion counts, sex hormone binding globulin, free androgen index, insulin-like growth factor-I, and insulin-like growth factor binding proteins.
Results |
At 12 weeks, total lesion counts had decreased more in the experimental group (−21.9 [95% confidence interval, −26.8 to −19.0]) compared with the control group (−13.8 [−19.1 to −8.5], P = .01). The experimental diet also reduced weight (P = .001), reduced the free androgen index (P = .04), and increased insulin-like growth factor binding protein-1 (P = .001) when compared with a high glycemic–load diet.
Limitations |
We could not preclude the role of weight loss in the overall treatment effect.
Conclusion |
This suggests nutrition-related lifestyle factors play a role in acne pathogenesis. However, these preliminary findings should be confirmed by similar studies.
Le texte complet de cet article est disponible en PDF.Abbreviations used : BMI, CV, DHEAS, FAI, GI, HOMA-IR, IGF, IGFBP, LGL, PCOS, SHBG
Plan
| The study was supported by a research grant from Meat and Livestock Australia. Disclosure: This study was the responsibility of the investigators. Meat and Livestock Australia had no role in data collection, data analysis, data interpretation, or submission for publication. Ms Smith receives a postgraduate scholarship from MINTRAC (National Meat Industry Training Council of Australia). Authors Mann, Braue, Mäkeläinen, and Varigos had no conflicts of interest to disclose. Presented at the 15th Congress of the European Academy of Dermatology and Venereology Meeting in Rhodes, October 5, 2006, and at the Nutrition Society of Australia Meeting in Melbourne, December 2, 2005. |
Vol 57 - N° 2
P. 247-256 - août 2007 Retour au numéro
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