Open-label trial of cyclosporine for vulvar lichen sclerosus - 19/08/11
Bursa, Turkey
Abstract |
Background |
Lichen sclerosus (LS) is a chronic inflammatory disease of skin and mucosal surfaces which is generally difficult to treat.
Objective |
We evaluated the efficacy of oral cyclosporine in refractory vulvar LS.
Methods |
Five patients with refractory vulvar LS were treated with oral cyclosporine (3-4 mg/kg/d) for 3 months. They were followed up on a monthly basis.
Results |
At the end of the treatment, the mean total symptom score regressed significantly and clinical findings such as erythema and erosion showed marked improvement. Mild adverse effects were seen in 3 patients.
Limitations |
The patients did not give consent to rebiopsy at the end of the treatment.
Conclusion |
Moderate dose of oral cyclosporine could be an effective alternative in the treatment of refractory vulvar LS.
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Funding sources: None. Conflicts of interest: None declared. |
Vol 57 - N° 2
P. 276-278 - août 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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