Site-specific protective effect of broad-spectrum sunscreen on nevus development among white schoolchildren in a randomized trial - 21/08/11
Vancouver and Burnaby, British Columbia, Canada
Abstract |
Background |
Melanocytic nevus density is a strong risk factor for cutaneous malignant melanoma. Reducing the number of nevi in children may reduce the risk of their developing melanoma as adults.
Objective |
We sought to assess the effect of sunscreen use on nevus development by anatomic sites and by nevi of different sizes for white schoolchildren in a randomized trial.
Methods |
We compared the new nevus count between the sunscreen intervention group (n=145) and the control group (n=164) by anatomic site.
Results |
Children randomized to the sunscreen group had significantly fewer new nevi on the trunk than children in the control group. The differences were more pronounced among the freckled children than children with no freckles.
Limitations |
Potential limitations to this study include relatively small numbers of enrolled children, and a follow-up period of only 3 years.
Conclusion |
Sunscreen use attenuated new nevus development on intermittently sun-exposed body sites for white schoolchildren, particularly among the freckled children.
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Supported by the British Columbia Health Research Foundation grant 161(91-1); the Medical Research Council of Canada, grant MA-13255; and Health Canada through the Action Plan for Health and the Environment. Sunscreen (PreSun Ultra 30) for the trial was provided by Westwood-Squibb Pharmaceuticals, Buffalo, New York. The authors have no financial relationship with any of the funding agencies for the study or with Westwood-Squibb Pharmaceuticals. Reprints are not available from the authors. |
Vol 52 - N° 5
P. 786-792 - mai 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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