Primary cicatricial alopecia: Histopathologic findings do not distinguish clinical variants - 21/08/11
San Francisco, California; Ann Arbor, Michigan; and Philadelphia, Pennsylvania
Abstract |
Background |
Primary cicatricial alopecias encompass a group of disorders characterized by permanent destruction of the hair follicle. The varied clinical features and differences in terminology have led to difficulties in defining consistent clinicopathologic correlation.
Objective |
We sought clinicopathologic correlation of 6 clinically distinct primary cicatricial alopecias: lichen planopilaris, frontal fibrosing alopecia, pseudopelade (Brocq), central centrifugal alopecia, folliculitis decalvans, and tufted folliculitis.
Methods |
We conducted prospective and blinded histopathologic evaluation of clinically typical primary cicatricial alopecias. Biopsy specimens were taken from early affected scalp lesions and paired with samples from clinically unaffected areas in the same patient.
Results |
The lymphocytic and neutrophilic groups were readily distinguished histologically. However, within the two groups clinically distinct primary cicatricial alopecias could not be distinguished with current histopathologic techniques.
Conclusion |
A descriptive, standardized histopathologic reporting of follicular architecture, type, location, and extent of the inflammatory infiltrate, and presence or absence of sebaceous glands, may be of greatest value in guiding the treatment of patients with primary cicatricial alopecias.
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Dr Headington is now retired. Dr Mirmirani is now affiliated with University Hospitals of Cleveland and Case Western Reserve University. Dr Willey is now a dermatology resident at the University of Minnesota. Supported by Cicatricial Alopecia Research Fund. Conflicts of interest: None identified. Presented in poster form at the Society for Investigative Dermatology Meeting, Miami, Florida, May, 2003. |
Vol 52 - N° 4
P. 637-643 - avril 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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