Subepidermal blistering disease with autoantibodies to both the p200 autoantigen and the ⍺3 chain of laminin 5 - 21/08/11
Reprint requests: Detlef Zillikens, MD, Department of Dermatology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.Lübeck and Freiburg, Germany
Abstract |
Anti-p200 pemphigoid and anti-laminin 5 mucous membrane pemphigoid are two distinct autoimmune blistering skin diseases. Patients with anti-p200 pemphigoid demonstrate circulating autoantibodies to an unknown 200-kd acidic noncollagenous glycoprotein of the lower lamina lucida, whereas anti-laminin 5 mucous membrane pemphigoid is characterized by an autoimmune response against the major basement membrane adhesion molecule laminin 5. In this report, we describe a patient who developed a recurrent nonscarring blistering eruption, affecting both skin and mucous membranes. Immunoblotting of dermal extracts and extracellular matrix of cultured keratinocytes revealed circulating autoantibodies directed to the p200 antigen and the ⍺3 chain of laminin 5, respectively. The unusual clinical and immunologic profile of this case suggests that molecular specificity of circulating autoantibodies affects the clinical presentation of autoimmune subepidermal blistering skin diseases.
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| This supplement is made possible through the generous support of Stiefel Laboratories for the American Academy of Dermatology. Supported by grant Zi 439/6-1 from the Deutsche Forschungsgemeinschaft. Conflicts of interest: None identified. |
Vol 52 - N° 5S
P. S90-S92 - mai 2005 Retour au numéro
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