Increased prevalence of chronic autoimmune (Hashimoto's) thyroiditis in children and adolescents with vitiligo - 21/08/11
, Christina Kanaka-Gantenbein, MD, Anna Papadopoulou, MD, Eirini Kaloumenou, MD, George P. Chrousos, MD
Reprint requests: Talia Kakourou, MD, First Department of Pediatrics, Athens University Medical School, “Aghia Sophia” Children's Hospital, 11527 Athens, Greece.Athens, Greece
Abstract |
Background |
An increased prevalence of autoimmune (Hashimoto's) thyroiditis in adult patients with vitiligo has been described. This association has scarcely been studied in children.
Objective |
We sought to assess children and adolescents with vitiligo for autoimmune thyroid disorder and to identify any predisposing factors of this association.
Methods |
In all, 54 children and adolescents (23 boys, 31 girls; mean age 11.4 years) with known vitiligo were studied by physical examination and laboratory studies.
Results |
Four patients with vitiligo were already known to have Hashimoto's thyroiditis. In 9 of the remaining 50 patients, autoimmune thyroiditis was revealed at the time of the investigation. Of the 54 patients with vitiligo, 13 (24.1%) had autoimmune thyroiditis as compared with 9.6% of school-aged children from an iodine-replete area of Greece (P=.002). There was no association between thyroiditis and clinical type of vitiligo, age at onset, mean duration of vitiligo, or sex.
Conclusions |
Hashimoto's thyroiditis is 2.5 times more frequent among children and adolescents with vitiligo than in a healthy age- and sex-matched population. It usually follows the onset of vitiligo. We propose that children and adolescents with vitiligo should be screened annually for thyroid dysfunction, particularly autoimmune thyroiditis.
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| Funding sources: None. Conflicts of interest: None identified. |
Vol 53 - N° 2
P. 220-223 - août 2005 Retour au numéro
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