IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin ⍺3 chain in a patient with an autoimmune subepidermal blistering disease - 21/08/11
, Cassian Sitaru, MD, PhD d
Correspondence to: Detlef Zillikens, MD, Department of Dermatology, University of Lübeck, Ratzeburger Allee, 160, 23538 Lübeck, Germany.Cluj-Napoca, Romania; Nagoya, Japan; Milwaukee, Wisconsin; and Lübeck, Germany
Abstract |
We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.
Le texte complet de cet article est disponible en PDF.Plan
| Funding source: Grant Zi 439/6-1 from the Deutsche Forschungsgemeinschaft. Conflict of interest: None identified. Reprints not available from the authors. |
Vol 53 - N° 3
P. 516-521 - septembre 2005 Retour au numéro
Article précédent
- Cutaneous lymphoid hyperplasia and marginal zone B-cell lymphoma following vaccination
- Steve A. May, George Netto, Rana Domiati-Saad, Candace Kasper
- Escharotic agents, Fred Mohs, and Harry Hoxsey
- Dirk M. Elston
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?