In situ eosinophil activation in 26 primary cutaneous T-cell lymphomas with blood eosinophilia - 21/08/11

Doi : 10.1016/j.jaad.2004.03.003

Marius A. Ionescu, MD ^a,^c, Jacqueline Rivet, MD ^b,^c, Marjan Daneshpouy, MD, PhD ^b,^c, Josette Briere, MD ^b,^c, Patrice Morel, MD ^a, Anne Janin, MD, PhD ^b,^c,^⁎
^a From the Departments of Dermatology
^b Pathology
^c ERM 0220 INSERM/Hematology Institute IFR 105, Saint-Louis Hospital University Paris VII

Reprint requests: Anne Janin, MD, PhD, Laboratoire de Recherche de Pathologie ERM 0220 INSERM, Université Paris 7, Institut Universitaire d'Hématologie, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France.

Paris, France

Abstract

Blood and tissue eosinophils can be associated with Hodgkin and non-Hodgkin lymphomas in that they have prognostic value. Tissue eosinophils in T-cell lymphoma patients with blood eosinophilia have not been systematically assessed. The objective of this research was to study the presence, density, and activation of tissue eosinophils in patients with primary cutaneous T-cell lymphomas (CTCLs) with blood eosinophilia and a possible relationship between features of the disease and prognosis. With skin biopsy specimens from 26 CTCL patients with blood eosinophilia, tissue eosinophils were studied with electron microscopy, extracellular eosinophil peroxidase deposits, and interleukin-5 expression. Tissue eosinophils, found in 22 of 26 cases, were constantly activated. Both density and activation of tissue eosinophils were significantly related to disease progression. The state of activation of tissue eosinophils in CTCL might reflect inflammatory flare-ups associated with aggressive lymphomas. Further studies are needed to confirm the value of eosinophil density as a simple and reliable marker of CTCL progression.

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Abbreviations used : ATLL, CTCL, EORTC, EPO, HD, IL, LDH, MF, SS, Th2