Agminated acquired melanocytic nevi of the common and dysplastic type - 21/08/11
New York, New York
Abstract |
We previously reported a single case of agminated acquired melanocytic nevi, consisting of a localized clustering of banal and atypical moles. We now report 4 more cases, confirming that the initial case was not an isolated finding. We examined the lesions clinically, with a dermoscope, with a Wood's light, and in 3 cases with UV photography so as to exclude nevus spilus from the differential diagnosis. The presence of an underlying dysplastic nevus syndrome phenotype in 4 of the 5 cases raises the possibility that agminated nevi arise as a consequence of postzygotic loss of heterozygosity and, thus, may represent a type 2 segmental manifestation of the atypical mole syndrome phenotype. Further studies of similar cases using microdissection techniques for analysis of loss of heterozygosity pattern are warranted.
Le texte complet de cet article est disponible en PDF.Abbreviations used : DN, DNS, LOH, UVR
Plan
Funding sources: None. Conflicts of interest: None identified. |
Vol 52 - N° 1
P. 67-73 - janvier 2005 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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