A systematic review of contact dermatitis treatment and prevention - 21/08/11
, Roohi Qureshi, MD, MEng, FRCPC a, b, Valerie Palda, MD, MSc, FRCPC c, Joel DeKoven, MD, MHSc, FRCPC a, b, Melanie Pratt, MD, FRCPC d, e, Sandy Skotnicki-Grant, MD, FRCPC a, b, Linn Holness, MD, MHSc, FRCPC a, b
Reprint requests: Joan Saary, MD, MSc, FRCPC, Department of Occupational and Environmental Health, St Michael's Hospital, 4th Floor Shuter Wing, 30 Bond St, Toronto, Ontario M5B 1W8, Canada.Toronto and Ottawa, Ontario, Canada
Abstract |
Background |
Contact dermatitis (CD) is a common occupational disease. There have been no systematic reviews of CD treatment or prevention.
Methods |
Multiple databases were systematically searched. Using independent double review and published quality review criteria, articles were rated as good, fair, or poor. Treatment benefit data were tabulated and conclusions were based on the rated strength of published evidence.
Results |
In all, 49 studies met inclusion criteria. Barrier creams containing dimethicone or perfluoropolyethers, cotton liners, and softened fabrics prevent irritant CD. Lipid-rich moisturizers both prevent and treat irritant CD. Topical skin protectant and quaternium 18 bentonite (organoclay) prevent rhus dermatitis. Diethylenetriamine pentaacetic acid (chelator) cream prevents nickel, chrome, and copper dermatitis. Potent or moderately potent steroids effectively treat allergic CD. There were no macrolide immunomodulator trials that met inclusion criteria. This review did not include studies of children, animals, or non-English language publications.
Conclusions |
A limited number of interventions effectively prevent or treat irritant and allergic CD, but well-controlled, outcome-blinded studies, particularly in the area of allergic CD prevention are needed.
Le texte complet de cet article est disponible en PDF.Abbreviations used : ACD, CD, ICD, OCD, TEWL, WSIB
Plan
| Funding source: The Workplace Safety and Insurance Board of Ontario. Conflicts of interest: None identified. This work has been provided to the Workplace Safety and Insurance Board as a technical report and has been orally presented at the Annual Meeting of the American Contact Dermatitis Society in Washington, DC, on February 5, 2004. |
Vol 53 - N° 5
P. 845.e1-845.e13 - novembre 2005 Retour au numéro
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