Higher prevalence of human herpesvirus 8 DNA sequence and specific IgG antibodies in patients with pemphigus in China - 21/08/11
Reprint requests: Hong-Duo Chen, MD, Department of Dermatology, No. 1 Hospital of China Medical University, 155 N Nanjing St, Shenyang 110001 China.Shenyang and Xiamen, China; Atlanta, Georgia; and Tokyo, Japan
Abstract |
Background |
Environmental factors, including virus infection, may play a role in the onset and/or development of pemphigus. However, it is controversial whether human herpesvirus (HHV)-8 is involved in pathogenesis of pemphigus.
Objective |
The possible association of pemphigus with HHV-8 was investigated.
Methods |
A total of 36 lesional skin and 13 peripheral blood mononuclear cell specimens from 58 patients with pemphigus, and 18 normal skin and 230 peripheral blood mononuclear cell specimens from healthy individuals, were tested for HHV-8 DNA sequence by a nested polymerase chain reaction assay. In all, 29 sera from the patients and 109 sera from healthy individuals were tested for HHV-8-specific IgG antibodies by enzyme-linked immunosorbent assays using HHV-8-specific oligopeptides as antigens.
Results |
Prevalence of both HHV-8 DNA sequence (36.1% and 30.8% in lesional skin and in peripheral blood mononuclear cells, respectively) and HHV-8-specific IgG antibodies (34.5%) for patients with pemphigus was statistically higher than that of control subjects (<8% in both assays). There was no significant difference in HHV-8 prevalence among different types of pemphigus.
Conclusion |
HHV-8 infection might be a contributing factor in the development of pemphigus.
Le texte complet de cet article est disponible en PDF.Abbreviations used : ELISA, HHV, KS, ORF, PBMC, PCR, PF, PV
Plan
| Supported by the Biological Research Fund of China Medical University. Conflicts of interest: None identified. |
Vol 52 - N° 3
P. 460-467 - mars 2005 Retour au numéro
Article précédent
- Epidemiology of sporotrichosis: A study of 304 cases in Brazil
- Ana Cecília Michel da Rosa, Maria Lúcia Scroferneker, Rodrigo Vettorato, Roberto Lopes Gervini, Gerson Vettorato, Analupe Weber
- Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors
- Tracy J. Lovatt, John T. Lear, Jean Bastrilles, Christina Wong, Christopher E.M. Griffiths, Venura Samarasinghe, Jamie Roebuck, Sudarshan Ramachandran, Andrew G. Smith, Peter W. Jones, Anthony A. Fryer, Richard C. Strange
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?