Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for port-wine stains - 21/08/11

Doi : 10.1016/j.jaad.2004.10.876

Marjorie U. Yang, MD ^a,^c, Anna N. Yaroslavsky, PhD ^a, William A. Farinelli ^a, Thomas J. Flotte, MD ^a,^b, Francisca Rius-Diaz, PhD ^a,^d, Sandy S. Tsao, MD ^a, R. Rox Anderson, MD ^a,^⁎
^a From the Department of Dermatology
^b Dermatopathology Unit
^c The Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School; Department of Medicine (Dermatology), St Luke's Medical Center, Quezon City
^d Department of Biostatistics and Public Health, University of Malaga

Reprint requests: R. Rox Anderson, MD, The Wellman Center for Photomedicine, Massachusetts General Hospital, BHX 630, 55 Fruit St, Boston, MA 02114.

Boston, Massachusetts; Quezon City, Philippines; and Malaga, Spain

Abstract

Objective

Laser treatment of port-wine stain (PWS) might be improved using a deeply penetrating wavelength.

Methods

PWSs in 17 patients were treated 3 times with a 595-nm pulsed dye laser (PDL) and a 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Fluences of 1.0, 0.8, and 0.6 times the minimum purpura dose (MPD) were used for Nd:YAG laser. Posttreatment biopsy specimens were taken. Blind assessment and quantitative analysis of PWS clearing were performed from digital photographs.

Results

MPD for Nd:YAG laser varied widely, from 40 to 250 J/cm². Purpura lasted longer after PDL. Treatment achieved similar 50% to 75% clearing with both PDL and Nd:YAG laser at 1 MPD. Nd:YAG caused greater perivascular and epidermal injury. Scarring occurred in the only patient treated with a Nd:YAG fluence greater than 1 MPD. Patients preferred Nd:YAG laser because of their faster recovery.

Conclusion

Nd:YAG laser used at MPD is as effective as PDL for treating PWS. Nd:YAG laser fluences higher than MPD may cause scarring.

Le texte complet de cet article est disponible en PDF.

Abbreviations used : B, G, met-Hb, MPD, Nd:YAG, OD, PDL, PWS, R, VAS

Plan

Gross and microscopic findings

Patient satisfaction

Discussion

Supported by a Massachusetts General Hospital grant.
Conflicts of interest: None identified.
Presented at the 23rd Annual Meeting of the American Society for Laser Medicine and Surgery, Anaheim, California, April 9-13, 2003.

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Vol 52 - N° 3

P. 480-490 - mars 2005 Retour au numéro

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Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for port-wine stains - 21/08/11

Abstract

Objective

Methods

Results

Conclusion

Plan

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