Defining early mycosis fungoides - 21/08/11

Doi : 10.1016/j.jaad.2005.08.057

Nicola Pimpinelli, MD ^a, Elise A. Olsen, MD ^c, Marco Santucci, MD ^b, Eric Vonderheid, MD ^d, Andreas C. Haeffner, MD ^e, Seth Stevens, MD ^f, Guenter Burg, MD ^e, Lorenzo Cerroni, MD ^g, Brigitte Dreno, MD ^h, Earl Glusac, MD ⁱ, Joan Guitart, MD ^j, Peter W. Heald, MD ⁱ, Werner Kempf, MD ^e, Robert Knobler, MD ^k, Stuart Lessin, MD ^l, Christian Sander, MD ^m, Bruce S. Smoller, MD ⁿ, Gladys Telang, MD ^o, Sean Whittaker, MD ^p, Keiji Iwatsuki, MD, PhD ^q, Erik Obitz, MD ^r, Masahiro Takigawa, MD ^s, Maria L. Turner, MD ^t, Gary S. Wood, MD ^u,^⁎
for the International Society for Cutaneous Lymphoma
^a From the Department of Dermatological Sciences
^b Department of Human Pathology and Oncology
^c University of Florence; Division of Dermatology, Duke University, Durham
^d Department of Dermatology, Johns Hopkins University, Baltimore
^e Department of Dermatology, University of Zurich
^f Amgen, Inc, Thousand Oaks
^g Department of Dermatology, University of Graz
^h Department of Dermatology, CHU Nantes
ⁱ Department of Dermatology, Yale University, New Haven
^j Department of Dermatology, Northwestern University, Chicago
^k Division of Special and Environmental Dermatology, Medical University of Vienna
^l Division of Dermatology, Fox Chase Cancer Center, Philadelphia
^m Department of Dermatology, University of Munich
ⁿ Department of Pathology, University of Arkansas, Little Rock
^o Department of Dermatology, Brown University, Providence
^p St John’s Institute of Dermatology, guys and St Thomas’ Hospital NHS Trust, Skin Cancer Unit, Division of Skin Sciences KCL, London
^q Department of Dermatology, Okayama University
^r Department of Dermatology, University of Aarhus
^s Department of Dermatology, Hamamatsu University
^t Dermatology Branch, National Cancer Institute, Bethesda
^u Department of Dermatology, University of Wisconsin and Veterans Affairs Medical Center, Madison

Reprint requests: Gary S. Wood, MD, Department of Dermatology, University of Wisconsin, One South Park, 7th Floor, Madison, WI 53715.

Florence, Italy; Durham, North Carolina; Baltimore, Maryland; Zurich, Switzerland; Thousand Oaks, California; Cleveland, Ohio; Graz and Vienna, Austria; Nantes, France; New Haven, Connecticut; Chicago, Illinois; Philadelphia, Pennsylvania; Munich, Germany; Little Rock, Arkansas; Providence, Rhode Island; London, United Kingdom; Okayama and Hamamatsu, Japan; Aarhus, Denmark; Bethesda, Maryland; and Madison, Wisconsin

Abstract

This editorial review summarizes the results of 5 meetings sponsored by the International Society for Cutaneous Lymphoma at which the clinicopathologic and ancillary features of early mycosis fungoides were critically examined. Based on this analysis, an algorithm was developed for the diagnosis of early mycosis fungoides involving a holistic integration of clinical, histopathologic, immunopathologic, and molecular biological characteristics. A novel aspect of this algorithm is that it relies on multiple types of criteria rather than just one, for example, histopathology. Before its finalization, the proposed diagnostic algorithm will require validation and possibly further refinement at multiple centers during the next several years. It is anticipated that a more standardized approach to the diagnosis of early mycosis fungoides will have a beneficial impact on the epidemiology, prognostication, treatment, and analysis of clinical trials pertaining to this most common type of cutaneous lymphoma.

Le texte complet de cet article est disponible en PDF.

Abbreviations used : CI, CTCL, DGGE, ISCL, MF, OR, PCR, PEP

Plan

Relationship between MF and parapsoriasis en plaques: Historical perspective and current implications

Early diagnosis of MF: The role of clinical assessment

A. History

B. Morphology of lesions

C. Number of lesions

D. Distribution of lesions

Early diagnosis of MF: The role of histopathology

Early diagnosis of MF: The role of ancillary techniques

Diagnostic algorithm: An ISCL proposal

Clinical criteria

Histopathologic criteria

Molecular biological criteria

Immunopathologic criteria

Caveats concerning the algorithm

Conclusions

Funding sources: Research funding provided by the Department of Veterans Affairs and National Institutes of Health grant AR-02136 (to G. S. W.).
Conflicts of interest: None identified.
Parts of this work have been presented at international meetings.

Export

Vol 53 - N° 6

P. 1053-1063 - décembre 2005 Retour au numéro

Article précédent

Osteopathic medicine and the practice of dermatology: History and current status : An overview of the American Osteopathic College of Dermatology, an affiliate specialty college of the American Osteopathic Association
Erik Austin, Bill V. Way, Chava Lustig, Jason Green, Christopher Manlio, Amy Broomer, Greg Persichetti, Asfa Akhtar, Merrick Elias, Tracy Favreau, Stanley Skopit

| Article suivant

Medical Pearl: Sarcoidosis prognosis
Jacob Levitt

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Defining early mycosis fungoides - 21/08/11

Abstract

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL