Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: A study of cases from an Internet-based registry - 21/08/11
Reprint requests: Ashfaq A. Marghoob, MD, Dermatology Service, Memorial Sloan-Kettering Cancer Center, 160 E 53 St, New York, NY 10022.New York, New York
Abstract |
Background |
Recent retrospective studies using magnetic resonance imaging (MRI) to screen for neurocutaneous melanocytosis (NCM) among neurologically asymptomatic children with large congenital melanocytic nevi (LCMN) report high prevalence (23-30%) of asymptomatic NCM. We sought to determine prevalence of asymptomatic NCM, and current application of MRI as a screening tool.
Methods |
Patients with LCMN from an Internet-based registry answered a questionnaire regarding NCM status.
Results |
Of 379 patients with LCMN, 26 reportedly had NCM, with 17 reporting neurologic symptoms. Of 186 patients undergoing MRI, 9 reported abnormal findings without neurologic symptoms (4.8%); 80% had LCMN on the posterior axis, whereas 55% had more than 20 satellite nevi.
Limitations |
Study data rely on the registry members' self-reported findings and are limited by lack of independent data verification.
Conclusion |
Asymptomatic NCM (determined by MRI) may not be common, with much lower prevalence (4.8%) than previously reported. MRI is widely used for screening patients at risk for NCM, such as patients with LCMN involving the posterior axis and greater than 20 satellite nevi.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CMN, CNS, LCMN, MRI, NCM, NOI
Plan
| Funding sources: None. Conflicts of interest: None identified. Presented as a poster at the Society of Investigative Dermatology 2005 Annual Meeting, St Louis, Missouri, May 5-7, 2005. |
Vol 53 - N° 6
P. 959-965 - décembre 2005 Retour au numéro
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?