Combined serum and nuchal translucency screening in the first trimester achieves 85% to 90% detection rate for Down and Edward syndromes - 24/08/11
Abstract |
Question |
How accurate is combined screening, based on maternal age, using serum and nuchal translucency measurements in first trimester screening for Down and Edward syndromes?
Study design |
Cohort study.
Main results |
Combined screening identified 85.2% (95% CI 73.8 to 93.0%) of babies with Down syndrome with a false positive rate of 9.4% (95% CI 8.8 to 10.1%). In women over 35 years, 89.8% cases were identified and the false positive rate increased to 15.2%. Combined screening identified 90.9% (95% CI 58.7 to 99.8%) of babies with Edward syndrome (trisomy 18) with a false positive rate of 2% (95% CI 1.7 to 2.3). All cases of trisomy 18 were identified among women over 35 years (n=8). Combined screening was significantly better than use of serum markers alone (p=0.002) but no more accurate than use of nuchal translucency alone (p=0.28).
Authors’ conclusions |
Combined screening for Edward and Down syndromes during the first trimester achieved detection rates of 90% and 85%, respectively, with acceptable false positive rates.
Le texte complet de cet article est disponible en PDF.Keywords : Prenatal diagnosis, Down Syndrome, Edward syndrome, Pregnancy, Maternal age sensitivity and specificity, Nuchal translucency
Plan
 | Abstracted from: Wapner R, Thom E, Simpson JL et al. First-trimester screening for trisomies 21 and 18. N Engl J Med 2003; 349: 1405–1413. |
Vol 8 - N° 2
P. 82-84 - avril 2004 Retour au numéro
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