What is the short-term risk of disease progression in children infected perinatally with HIV-1?
Eight cohort studies and nine randomized controlled trials in 3941 children infected perinatally with HIV-1 were identified. The risk of AIDS or death increased across all age groups with decreasing CD4 T cell percentage (CD4%). Children aged ≤2 years had the most pronounced increase in risk within 12 months with decreasing CD4% compared with children aged 5 to 10 years (CD4%1 at which probability of death increases: 20% to 25% for children aged 6 months to 2 years vs. 10% to 15% for children aged 5 to 10 years; CD4% at which probability of AIDS increases: 25% to 30% for children aged 6 months to 2 years vs. 12% to 20% for children aged 5 to 10 years). Risk of disease progression increased with increasing viral load although the correlation was more gradual compared with CD4%.
Risk of disease progression in children infected with HIV-1 is strongly associated with low CD4%, particularly in children aged ≤2 years.Le texte complet de cet article est disponible en PDF.
Keywords : AIDS, HIV, Children, Disease progression, Risk, Mortality, Meta-analysis
| Abstracted from: HIV Paediatric Prognostic Markers Collaborative Study Group. Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis. Lancet 2003; 362: 1605–1611.