Risk of AIDS increases in children aged 2 years and older with CD4 T cell percentage less than 15% - 24/08/11
Abstract |
Question |
What is the short-term risk of disease progression in children infected perinatally with HIV-1?
Study design |
Meta-analysis.
Main results |
Eight cohort studies and nine randomized controlled trials in 3941 children infected perinatally with HIV-1 were identified. The risk of AIDS or death increased across all age groups with decreasing CD4 T cell percentage (CD4%). Children aged ≤2 years had the most pronounced increase in risk within 12 months with decreasing CD4% compared with children aged 5 to 10 years (CD4%1 at which probability of death increases: 20% to 25% for children aged 6 months to 2 years vs. 10% to 15% for children aged 5 to 10 years; CD4% at which probability of AIDS increases: 25% to 30% for children aged 6 months to 2 years vs. 12% to 20% for children aged 5 to 10 years). Risk of disease progression increased with increasing viral load although the correlation was more gradual compared with CD4%.
Authors’ conclusions |
Risk of disease progression in children infected with HIV-1 is strongly associated with low CD4%, particularly in children aged ≤2 years.
Le texte complet de cet article est disponible en PDF.Keywords : AIDS, HIV, Children, Disease progression, Risk, Mortality, Meta-analysis
Plan
Abstracted from: HIV Paediatric Prognostic Markers Collaborative Study Group. Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis. Lancet 2003; 362: 1605–1611. |
Vol 8 - N° 3
P. 168-170 - juin 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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