Risk of AIDS increases in children aged 2 years and older with CD4 T cell percentage less than 15% - 24/08/11

Doi : 10.1016/j.ehbc.2004.03.019

William J Moss, MD,MPH ^a : Commentary Author, Deborah Persaud, MD ^b : Commentary Author
^a Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
^b Johns Hopkins University School of Medicine, 600 North Wolfe Street, Park 256, Baltimore, MD 21287, USA

Abstract

Question

What is the short-term risk of disease progression in children infected perinatally with HIV-1?

Study design

Meta-analysis.

Main results

Eight cohort studies and nine randomized controlled trials in 3941 children infected perinatally with HIV-1 were identified. The risk of AIDS or death increased across all age groups with decreasing CD4 T cell percentage (CD4%). Children aged ≤2 years had the most pronounced increase in risk within 12 months with decreasing CD4% compared with children aged 5 to 10 years (CD4%^{^{1Estimates are approximate as data were presented graphically.}} at which probability of death increases: 20% to 25% for children aged 6 months to 2 years vs. 10% to 15% for children aged 5 to 10 years; CD4% at which probability of AIDS increases: 25% to 30% for children aged 6 months to 2 years vs. 12% to 20% for children aged 5 to 10 years). Risk of disease progression increased with increasing viral load although the correlation was more gradual compared with CD4%.

Authors’ conclusions

Risk of disease progression in children infected with HIV-1 is strongly associated with low CD4%, particularly in children aged ≤2 years.

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Keywords : AIDS, HIV, Children, Disease progression, Risk, Mortality, Meta-analysis

Plan

Commentary

Implications

Study parameters

Abstracted from: HIV Paediatric Prognostic Markers Collaborative Study Group. Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis. Lancet 2003; 362: 1605–1611.

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Vol 8 - N° 3

P. 168-170 - juin 2004 Retour au numéro

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Risk of AIDS increases in children aged 2 years and older with CD4 T cell percentage less than 15% - 24/08/11

Abstract

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Study design

Main results

Authors’ conclusions

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