What is the clinical impact of bleeding in people taking anticoagulants for venous thromboembolism?
Systematic review with meta-analysis.
Thirty-three studies met inclusion criteria (29 randomised controlled trials, 4 prospective cohort studies; 10,757 people). Major bleeding occurred in 27610,757 (2.6%) of people receiving anticoagulant therapy for venous thromboembolism (see Table 1). Intracranial bleeding accounted for 24276 (8.7%) of all major bleeding episodes with fatalities occurring in 1124 (45.8%) of these episodes.
Major bleeding associated with anticoagulant therapy has considerable clinical consequences that will need to be weighed against therapeutic benefits in people with venous thromboembolism.Le texte complet de cet article est disponible en PDF.
Keywords : Anticoagulants, Venous thromboembolism, Risk factors, Systematic review
| Abstracted from: Linkins LA, Choi PT, Douketis JD. Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism. A meta-analysis. Ann Intern Med 2003; 139: 893–900.