Incidental epidermolytic hyperkeratosis and focal acantholytic dyskeratosis in common acquired melanocytic nevi and atypical melanocytic lesions - 24/08/11
Abstract |
Background |
Epidermolytic hyperkeratosis (EH) and focal acantholytic dyskeratosis (FAD) are distinct histologic patterns that have been observed incidentally in a variety of benign and malignant skin lesions, including melanocytic lesions.
Objective |
Our motivation for this study was to determine whether FAD and/or EH was significantly associated with atypical melanocytic lesions.
Methods |
Skin biopsy specimens of melanocytic lesions diagnosed at our facility over a 3-month period were examined for the occurrence of FAD and EH.
Results |
Whereas both FAD and EH are uncommon findings, FAD was statistically increased in atypical melanocytic lesions (P = .0172). EH was not found to differ significantly in common acquired melanocytic nevi vs atypical melanocytic lesions.
Conclusions |
Although both can be found in association with nonneoplastic skin diseases, as well as cutaneous neoplasms, FAD, but not EH, might serve as a marker for melanocytic atypia. Taken together with findings in the literature, FAD might serve as marker for atypical cutaneous proliferations as a whole.
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Funded by the Department of Dermatology at the Medical University of South Carolina. Conflicts of interest: None identified. |
Vol 50 - N° 3
P. 388-390 - mars 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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