Lowering homocysteine levels does not reduce rates of stroke, coronary heart disease or death in people with ischaemic stroke - 24/08/11
Abstract |
Question |
Do high doses of vitamins B6 and B12 and folic acid, which lower total homocysteine levels, reduce the risk of recurrent stroke, myocardial infarction or death compared with low doses in people with non disabling acute ischaemic stroke?
Study design |
Multicentre randomised controlled trial.
Main results |
High dose vitamins reduced mean total homocysteine levels by 2 μmol/l more than low dose vitamins. In people surviving a non disabling acute ischaemic stroke, no significant differences in rates of recurrent ischaemic stroke, coronary heart disease or death occurred between people receiving high dose or low dose vitamins over 2 years (see Table 1).
|
Authors’ conclusions |
In people with ischaemic stroke, lowering homocysteine levels does not reduce the rate of recurrent stroke, coronary heart disease or death.
Le texte complet de cet article est disponible en PDF.Keywords : Stroke, Vitamins, Homocysteine, Risk factors, Cardiovascular diseases, Randomised controlled trial
Plan
Abstracted from: Toole JF, Malinow MR, Chambless LE et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death - The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 2004; 291: 565–575. |
Vol 8 - N° 4
P. 210-212 - août 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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