Clonal identity between skin and synovial tissue in a case of mycosis fungoides with polyarthritis - 24/08/11
Rotterdam and The Hague, The Netherlands
Abstract |
Polyarthritis in the presence of a cutaneous T-cell lymphoma is a rare phenomenon. We describe a case of mycosis fungoides with development of a symmetric erosive polyarthritis of the small hand joints and feet, diagnosed as rheumatoid arthritis. An identical monoclonal T-cell population in the skin and in the synovium was detected by T-cell receptor gene rearrangement analysis, illustrating articular dissemination of lymphoma cells. Differentiating mycosis fungoides–associated arthritis from rheumatoid arthritis may have important implications for treatment. Based on this case, the relevant literature, and the newest disease concepts, pathogenic mechanisms and therapeutic options of mycosis fungoides–associated arthritis are discussed.
Le texte complet de cet article est disponible en PDF.Abbreviations : DCLWG, LN, MF, RA, SB, TCR
Plan
Funding sources: None. Conflicts of interest: None identified. |
Vol 51 - N° 1
P. 111-117 - juillet 2004 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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