Localized linear IgA disease induced by ampicillin/sulbactam - 24/08/11
Reprint requests: Detlef Zillikens, MD, Department of Dermatology, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.Würzburg, Germany
Abstract |
We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.
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 | Supported by grant 98.073.2 from the Wilhelm Sander-Stiftung, Munich, Germany. Conflicts of interest: None identified. This work was presented at the 42nd Congress of the German Dermatological Society in Berlin, May 2003. |
Vol 51 - N° 1
P. 95-98 - juillet 2004 Retour au numéro
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