Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin - 24/08/11
Reprint requests: Salvador González, Md, PhD, Wellman Laboratories of Photomedicine, BHX 630, Massachusetts General Hospital, Boston, MA 02114.Boston, Massachusetts, and Malaga, Spain
Résumé |
Background |
UV radiation induces damage to human skin. Protection of skin by an oral photoprotective agent would have substantial benefits.
Objective |
We investigated the photoprotective effect of oral administration of an extract of the natural antioxidant Polypodium leucotomos (PL).
Methods |
A total of 9 healthy participants of skin types II to III were exposed to varying doses of artificial UV radiation without and after oral administration of PL (7.5 mg/kg). At 24 hours after exposure the erythema reaction was assessed and paired biopsy specimens were obtained from PL-treated and untreated skin.
Results |
A significant decrease in erythema was found in PL-treated skin (P < .01). Histologically, PL-treated biopsy specimens showed less sunburn cells (P < .05), cyclobutane pyrimidine dimers (P < .001), proliferating epidermal cells (P < .001), and dermal mast cell infiltration (P < .05). A trend toward Langerhans cell preservation was seen.
Conclusion |
Oral administration of PL is an effective systemic chemophotoprotective agent leading to significant protection of skin against UV radiation.
Le texte complet de cet article est disponible en PDF.Abbreviations used : CPD, MED, PL, UVR
Plan
| Dr González presently holds a joint appointment at the Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York. Supported by a research grant from Industrial Farmaceutica Cantabria, SA, Madrid, Spain. Conflicts of interest: None identified. Presented in part at the 20th World Congress of Dermatology, Paris, France, July 1-5, 2002. |
Vol 51 - N° 6
P. 910-918 - décembre 2004 Retour au numéro
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