An intraindividual comparative study of psoralen-UVA erythema induced by bath 8-methoxypsoralen and 4, 5′, 8-trimethylpsoralen - 29/08/11
Abstract |
Background: Limited work has been conducted on the characteristics of topical trimethylpsoralen (TMP) psoralen-UVA (PUVA) erythema. Objective: We sought to determine the time-course and dose-response characteristics of erythema induced by topical TMP, and to compare these parameters with those for topical 8-methoxypsoralen (MOP) within patients. Methods: After photosensitization of one forearm with topical TMP, test sites were exposed to a UVA dose series. The procedure was repeated on the other forearm using 8-MOP solution. Erythema was assessed visually and with a reflectance instrument every 24 hours for 7 days. Results: TMP PUVA erythema followed a similar time course to 8-MOP PUVA erythema. The majority of patients were at maximal erythema at or beyond 96 hours. TMP PUVA had a significantly steeper dose-response curve at 48, 72, and 96 hours compared with 8-MOP PUVA. Conclusion: On the basis of these data, the optimal time to read the TMP minimal phototoxic dose is 96 hours. In view of the steeper dose-response curve for TMP PUVA, a lower UVA incremental regimen should be considered compared with that for 8-MOP PUVA. (J Am Acad Dermatol 2003;49:59-64.)
Le texte complet de cet article est disponible en PDF.Abbreviations : D0.025, MOP, MPD, PUVA, TMP
Plan
Funding sources: None. |
|
Conflict of interest: None identified. |
|
Reprint requests: Sally H. Ibbotson, MD, Photobiology Unit, Department of Dermatology, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK. E-mail: s.h.ibbotson@dundee.ac.uk. |
|
0190-9622/2003/$30.00 + 0 |
Vol 49 - N° 1
P. 59-64 - juillet 2003 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?