Paraneoplastic pemphigus associated with uterine carcinoma - 29/08/11
Abstract |
Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease characterized by severe mucous membrane involvement, polymorphous skin eruptions, and underlying neoplasms, usually those of lymphoreticular system. Cases of PNP associated with solid cancer are extremely rare. A 46-year-old woman presented with severe stomatitis, pseudomembranous conjunctivitis, and polymorphous skin eruptions. Histologic, immunofluorescence, and immunoblot analyses confirmed the diagnosis of PNP. Whole-body examination revealed squamous cell carcinoma of the uterine cervix, but no hematologic tumors. Complete removal of the uterine tumor in addition to administration of betamethasone induced considerable improvement of cutaneous and mucous membrane lesions. To our knowledge, this is the first reported case of PNP associated with uterine carcinoma. (J Am Acad Dermatol 2003;48:S69-72.)
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This supplement is made possible through an unrestricted educational grant from Stiefel Laboratories to the American Academy of Dermatology. |
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Reprint requests: Yayoi Niimi, MD, Department of Dermatology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-0086 Japan. E-mail address: nimi@nms.ac.jp. |
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0190-9622/2003/$30.00 + 0 |
Vol 48 - N° 5S
P. S69-S72 - mai 2003 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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