DNA repair and nonmelanoma skin cancer in Puerto Rican populations - 29/08/11
Abstract |
Background |
UV radiation is a risk factor for nonmelanoma skin cancer (NMSC). The relation between DNA damage and oncogenesis suggests that diminished DNA repair capacity (DRC) is involved in tumorigenesis.
Objective |
The purpose of this study was to test the hypothesis that a low DRC is a susceptibility factor for the development of NMSC in Puerto Rico.
Methods |
A case-control retrospective clinical study was done to compare the age-adjusted DRC in participants with and without NMSC. DRC was measured using a host cell reactivation assay with a luciferase reporter gene irradiated with UV light and transfected into human peripheral lymphocytes. An epidemiologic questionnaire was used to solicit risk factors.
Results |
The mean (±2 SE) DRC of 177 control patients without skin cancer was 8.6% ± 0.7. Participants (280) with NMSC had a 42% lower DRC (5.0% ± 0.3).
Conclusion |
A low DRC is a susceptibility factor for NMSC.
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 | Supported by grants from the RCMI-NIH Program (grant 2G12 RR03050-17) and the National Aeronautic and Atmospheric Administration (grant NAG-2-1385) to Ponce School of Medicine through Dr Matta. Conflicts of interest: None identified. Accepted for publication December 14, 2002. |
Vol 49 - N° 3
P. 433-439 - septembre 2003 Retour au numéro
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